Clinical Significance Assignment Paper

Clinical Significance Assignment Paper

Findings can be clinically significant even if they are not statistically significant. Clinical significance refers to the practical significance of the research findings and therefore from a clinical perspective, the statistical significance is of limited value. According to Park (2016) findings that are not statistically significant do not automatically signify that the treatment was not significantly effective since factors such as measurement variability and sample sizes can influence statistical findings. This is in line with Schober et al (2018) who add that confidence intervals provide much more essential information that can be used to evaluate the significance of the study findings. Clinical Significance Assignment Paper


Clinical significance is not directly related to statistics, but it is an issue of judgment. Clinical significance is often dependent on the scale being studied. This is because to be clinically significant, a significant change in the findings should occur. Nonetheless, statistically, significant changes are observable even in small findings because statistical significance is strongly influenced by numerous observations.  Similarly, large studies can be significant and yet lack clinical significance and therefore statistically significant studies can be clinically important. Clinical Significance Assignment Paper

It is important to present clinically meaningful findings, and hence it is important to correctly interpret the findings to enable their implementation in clinical practice. Therefore, the interpretation of clinical findings is not supposed to be exclusively based on their statistical significance (Park, 2016). This is because there is the heterogeneity of patient samples, limitation on testing of the hypothesis, as well as small sample sizes and therefore clinical-pertinent measures like confidence intervals, effect size, clinically significant differences, as well as inferences based on magnitude should be considered.


Park S. (2016). Significant results: statistical or clinical? Korean J Anesthesiol. 69(2), 121–125.

Schober P, Bosses S & Lothar S. (2018). Statistical Significance Versus Clinical Importance of Observed Effect Sizes: What Do P Values and Confidence Intervals Really Represent? Anesth Analg. 126(3), 1068–1072. Clinical Significance Assignment Paper

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