DH’s daily medications are fluoxetine ,atorvastatin, lisinopril and diphenhydramine

DH, a 65-year-old female, recently met with her pharmacist for her semi-annual medication therapy review session. DH’s daily medications are fluoxetine (40 mg) for depression, atorvastatin (80 mg) for hyperlipidemia, lisinopril (20 mg) for hypertension, and diphenhydramine for allergies. Recently, after assessments indicating that she is at high risk for developing breast cancer, DH’s primary care physician prescribed tamoxifen (20 mg), which is approved in the US as a risk-reducing therapy. When her pharmacist asked about any new problems related to her medications, DH noted that since starting the tamoxifen, she has been experiencing hot flashes, fatigue, and pain in her joints. Her pharmacist replied that these are relatively normal side effects associated with tamoxifen. DH then asked about the safety of taking tamoxifen with all of her other medications.

Tamoxifen: Possible Drug Interactions and Alternatives?

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