Medication Used For Heart Failure Essay

Medication Used For Heart Failure Essay

Medication Used For Heart Failure


According to the American college of cardiology foundation, digoxin is the drug of choice in treatment of heart conditions such as atrial fibrillations and heart failure with reduced ejection fraction (Lam, et al, 2020). The dosage is initiated at 0.0625mg and maintained at 0.125mg daily. Its bioavailability is 60-80% and the onset of its effects is up to 2hours. It is protein-bound 25%, metabolized by the liver, and its half-life is 1-3 days. It is excreted in urine and feces. Medication Used For Heart Failure Essay


Mode Of Action

Digoxin exerts its positive inotropic events that promote myocardial contractility. The inotropic effects occur through the inhibition of the sodium-potassium pump at the cellular membrane. This causes an increase in intracellular sodium concentration, a decrease in potassium, and an increase in calcium at the cytoplasmic (Lam, et al, 2020). This will increase heart contractility and cardiac output. Digoxin has vogomimetic effects that inhibit the atrial ventricular node by stimulating the parasympathetic nervous system which slows the electrical conduction and hence a decrease in heart rate.

Adverse Effects And Monitoring

Digoxin can cause life-threatening and mild adverse effects after administration. Digoxin toxicity is the major cause of fatal cardiac arrhythmia (David, & Shetty, 2020). Other effects of digoxin are visual effects, tachycardia, vomiting, and anorexia. Before administration of digoxin, the nurse should ask about any recent change of medication to avoid drug toxicity. One should also evaluate the glomerular filtration rate, renal function, and regular electrocardiograms.

Drug Interaction

Digoxin cannot be administered along-side antibiotics such as azithromycin and clarithromycin because they increase the effect of digoxin by altering the intestinal flora (David, & Shetty, 2020). This may precipitate digoxin toxicity. It is also not co-administered with NSAIDs such as aceclofenac because both will increase serum potassium levels. Medication Used For Heart Failure Essay

Select a medication used in evidence-based treatment guidelines for the condition chosen in the first discussion question. Share the mechanism of action of this medication and hints for monitoring, side effects, and drug interactions of which one should be aware. Make sure that you select a different medication than your peers. Include the name of the medication in the subject line so that the medications can be followed. Include your references in APA style. Medication used for heart failure; do not do thiazide diuretics as someone already has taken it. Maybe dopamine or something else. MUST have 2 sources and cite page numbers. DOES NOT NEED COVER PAGE… its for a discussion post but needs to have APA citations. Include nursing education/implications.


David, & Shetty, (2020). Digoxin. StatPearls [Internet].

Lam, P. H., Packer, M., Gill, G. S., Wu, W. C., Levy, W. C., Zile, M. R., … & Ahmed, A. (2020). Digoxin initiation and outcomes in patients with heart failure with preserved ejection fraction. The American journal of medicine133(10), 1187-1194. Medication Used For Heart Failure Essay

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