Pathophysiology-Asthma essay paper

Pathophysiology-Asthma essay paper


Asthma is a chronic disease of the airway common in childhood characterized by difficulties in breathing and wheezing. Inflammation of the airway, airflow obstruction, and bronchiole hyper-responsiveness causes respiratory distress in acute exacerbation of asthma (Zahran, et al, 2018). Airway inflammation is a result of activated inflammatory cells and their mediators after exposure to allergens. These cause airway edema, bronchoconstriction, and mucus secretion thus contributing to airway obstruction and intermittent flow of the air. Genetic susceptibility and environmental factors contribute to asthma, especially in childhood. Pathophysiology-Asthma essay paper

Genetic Susceptibility That Can Lead To Childhood Asthma


Gene variations in encoding play a role in natural immune response pathways that contributes to the activation and differentiation of cells in the pathogenesis of asthma. The genome-wide association studies state that encoding of the thymic stromal lymphopoietin, epithelial cells derived cytokines, and interleukin-33 causes the activation of the T-helper cells in asthma (Johansson, et al, 2019). Association of gene variation 17q21 often replicated in childhood, is specific to the non-allergic and non-immune pathway of asthma. Gene 17q21 causes the activation of the IgE mediated pathway that causes inflammation and obstruction of the airway. Gene 17q21 and environmental exposure causes recurrent wheezing. The expression of ORMDL3 at the gene17q21 is associated with bronchial reactivity and asthma. Pathophysiology-Asthma essay paper

Environmental Factors That Can Lead To Childhood Asthma

Exacerbation of asthma depends on the interaction of the allergen exposure and presence of nonspecific adjuvants in genetically susceptible individuals (Johansson, et al, 2019). Environmental factors can be indoor or outdoor. Early exposure to allergens in childhood leads to the development of asthma. Common environmental factors causing asthma are pollution, cats, dogs, mold, and endotoxin. Exposure to these allergens triggers the production of immunoglobulin E-dependent mediators causing airway edema and obstruction. Pathophysiology-Asthma essay paper

Calculate the price
Make an order in advance and get the best price
Pages (550 words)
*Price with a welcome 15% discount applied.
Pro tip: If you want to save more money and pay the lowest price, you need to set a more extended deadline.
We know how difficult it is to be a student these days. That's why our prices are one of the most affordable on the market, and there are no hidden fees.

Instead, we offer bonuses, discounts, and free services to make your experience outstanding.
How it works
Receive a 100% original paper that will pass Turnitin from a top essay writing service
step 1
Upload your instructions
Fill out the order form and provide paper details. You can even attach screenshots or add additional instructions later. If something is not clear or missing, the writer will contact you for clarification.
hiw 01
Pro service tips
How to get the most out of your experience with Nursing Papers Writer
One writer throughout the entire course
If you like the writer, you can hire them again. Just copy & paste their ID on the order form ("Preferred Writer's ID" field). This way, your vocabulary will be uniform, and the writer will be aware of your needs.
The same paper from different writers
You can order essay or any other work from two different writers to choose the best one or give another version to a friend. This can be done through the add-on "Same paper from another writer."
Copy of sources used by the writer
Our college essay writers work with ScienceDirect and other databases. They can send you articles or materials used in PDF or through screenshots. Just tick the "Copy of sources" field on the order form.
See why 20k+ students have chosen us as their sole writing assistance provider
Check out the latest reviews and opinions submitted by real customers worldwide and make an informed decision.
Customer reviews in total
Current satisfaction rate
3 pages
Average paper length
Customers referred by a friend
15% OFF your first order
Use a coupon FIRST15 and enjoy expert help with any task at the most affordable price.
Claim my 15% OFF Order in Chat