Pharmacological Treatment of Migraine Assignment

Pharmacological Treatment of Migraine Assignment

Pain management

The physician prescribed Vicodin® 10/325 i-ii Q4-6h prn with a quantity of 120 for the whole month. Duration of action of Vicodin is 4-6 hours that’s why 4 tablets were enough for a day but due to severity of pain, he misused the drug and started to take more than the prescribed dose, 12 tablets per day resulting in dependency that’s why he requested for more refills about every 10-14 days (Caldwell, et al, 2019). The patient’s medication was changed to morphine because Vicodin is not more effective that’s why a stronger pain killer is required for his pain relief that is, extended-release morphine ( MS Contin) morphine sulfate. Morphine sulfate is extended-release and is required once a day or 1 tablet per day (24 hours) and a higher dose per capsule is 90-120mg. Pharmacological Treatment of Migraine Assignment


C.M. complains of a migraine headache at least two episodes every month. The most likely cause of headache is atopy because she is asthmatic. Atopic patients have a higher prevalence of experiencing asthmatic attacks. Other causes according to her presenting symptoms are anxiety and insomnia (Charles, A. 2018). Non-pharmacological interventions for this patient are avoiding asthmatic triggers such as dust, smoke, and pollen. The patient should develop healthy sleeping habits to avoid insomnia. She should also visit a psychotherapy counselor to manage the anxiety disorder.

Pharmacological treatment methods include the use of tricyclic anti-depressants such as amitriptyline 25mg at bedtime (de Vries, et al, 2020). This drug is effective in treating anxiety disorder, insomnia, and pain. The dosage is increased gradually two weeks after the initiation to attain its efficiency and effectiveness. The patient should continue with the inhaler

There are hundreds of opioid conversion calculators available online, though they are not all of good quality. I would like to direct you to one of the opioid conversion calculators that I find to be most useful and evidence based. Locate Pharmacological Treatment of Migraine Assignment and evaluate the following case using the calculator as necessary. Discuss your approach to the overall case and results of your calculation. A 79 year old white male is taking hydrocodone/APAP 10/325 for lower back pain (pt diagnosed with degenerative disc disease several months ago). The physician had written a prescription for Vicodin® 10/325 i-ii Q4-6h prn pain with a quantity of 120. Her expectation was that this would last the patient for one month. The patient is now requesting refills about every 10-14 days. He states he has been taking 2 tabs Q4h (12 tablets per day) because “the pain is so bad I just can’t stand it!”. What is the problem with the way the patient is taking this medication versus the way it was prescribed Based on your assessment, it is determined this patient should be converted to extended release morphine for better, more consistent pain control. Perform this conversion and provide an appropriate recommendation (drug, dose, frequency). Migraine is a major neurological disease that affects more than 36 million men, women and children in the United States. There is no cure for migraine. Most current treatments aim to reduce headache frequency and stop individual headaches when they occur. Let’s look at a case example: CM is 20 years old female with severe, prolonged 2 to 3 day migraines twice per month. She has difficulty sleeping and is mildly anxious. She occasionally utilizes an inhaler for asthma. Provide an evaluation of CM’s condition including non-pharmacological interventions and treatment options Is Cm a candidate for prophylactic therapy, and if so, what option would be best suited to her? Pharmacological Treatment of Migraine Assignment


Caldwell, W. K., Freedman, B., Settles, L., Thomas, M. M., Camacho, E. T., & Wirkus, S. (2019). The Vicodin abuse problem: A mathematical approach. Journal of theoretical biology483, 110003.

Charles, A. (2018). The pathophysiology of migraine: implications for clinical management. The Lancet Neurology17(2), 174-182.

de Vries, T., Villalon, C. M., & MaassenVanDenBrink, A. (2020). Pharmacological treatment of migraine: CGRP and 5-HT beyond the triptans. Pharmacology & therapeutics211, 107528. Pharmacological Treatment of Migraine Assignment

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